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pentobarbital will lower the extent or result of buprenorphine buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lessen the extent or influence of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.Observe Intently (one)pentobarbital will decrease the extent